β-arrestin 偏向性受体的结构快照。
Structural snapshot of a β-arrestin-biased receptor.
机构信息
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
出版信息
Trends Pharmacol Sci. 2023 Jan;44(1):1-3. doi: 10.1016/j.tips.2022.08.005. Epub 2022 Aug 31.
Abstract
Atypical chemokine receptor subtype 3 (ACKR3), a chemokine receptor, couples selectively to β-arrestins (βarrs) but not to G proteins despite having seven transmembrane (7TM) helix architecture. Yen et al. present cryogenic-electron microscopy (cryo-EM) structures of agonist-bound ACKR3, elucidating a distinct chemokine-binding mechanism, and offering a structural template to probe the transducer-coupling bias at this receptor.
摘要
非典型趋化因子受体亚型 3（ACKR3）是一种趋化因子受体，尽管具有七个跨膜（7TM）螺旋结构，但选择性地与β-arrestins（βarrs）偶联，而不与 G 蛋白偶联。Yen 等人介绍了激动剂结合的 ACKR3 的低温电子显微镜（cryo-EM）结构，阐明了一种独特的趋化因子结合机制，并提供了一个结构模板来探测该受体的转导偶联偏向。
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