Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008 Bern, Switzerland; Department for BioMedical Research, Radiation Oncology, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008 Bern, Switzerland; Department for BioMedical Research, Radiation Oncology, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Trends Cell Biol. 2023 Jan;33(1):5-8. doi: 10.1016/j.tcb.2022.08.002. Epub 2022 Sep 1.
Small proline-rich proteins (SPRRPs) are traditionally known for their function in keratinocyte homeostasis. Recent evidence demonstrates their involvement in additional diverse physiological processes ranging from p53 signaling and direct prevention of DNA damage to bactericidal activities. We highlight these novel, intriguing roles of SPRRPs and discuss them in the context of relevant pathological conditions.
小富含脯氨酸蛋白 (SPRRP) 传统上以其在角质形成细胞稳态中的功能而闻名。最近的证据表明，它们还参与了其他多种生理过程，包括 p53 信号传导和直接防止 DNA 损伤以及杀菌活性。我们强调了 SPRRP 的这些新颖而有趣的作用，并在相关病理条件的背景下对其进行了讨论。
