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对头颈部鳞状细胞癌样本组织匀浆中选定的富含脯氨酸的小蛋白的分析。

Analysis of Selected Small Proline-Rich Proteins in Tissue Homogenates from Samples of Head and Neck Squamous Cell Carcinoma.

作者信息

Nałęcz Dariusz, Świętek Agata, Hudy Dorota, Złotopolska Zofia, Opyrchał Jakub, Aebisher David, Strzelczyk Joanna Katarzyna

机构信息

Department of Otolaryngology and Maxillofacial Surgery, St. Vincent De Paul Hospital, 1 Wójta Radtkego St., 81-348 Gdynia, Poland.

Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 19 Jordana St., 41-808 Zabrze, Poland.

出版信息

Diagnostics (Basel). 2025 Jun 26;15(13):1633. doi: 10.3390/diagnostics15131633.

DOI:10.3390/diagnostics15131633
PMID:40647632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12248949/
Abstract

: Head and neck squamous cell carcinoma (HNSCC) ranks sixth in the world in terms of incidence. Small proline-rich proteins (SPRRs) are precursors of the keratinocyte envelope and act as substrates of transglutaminase. A change in SPRR expression is characteristic in a few types of cancer. Our aim was to determine the concentration of SPRR1A and SPRR2A in tumours samples obtained from 61 patients with HNSCC (OSCC, OPSCC, LSCC, HPSCC, NCSCC, and SSCC). Also, we aimed to determine the relationship between protein concentration and other clinical and/or demographic variables. An ELISA test was used to determine the concentrations of SPRR in the tumour tissue homogenates. : In margin samples, we found a statistically significant association between SPRR1A levels and nodal status (N) and between SPRR1A levels in tumours and margins with G2 histological grade. When we analysed the effect of tobacco and alcohol habits, we found a statistically significant difference between the SPRR1A and SPRR2A amount in smokers and non-smokers in margin samples. Also, we found a statistically significant difference between the SPRR1A and SPRR2A levels in tumour and margin samples obtained from patients that either abstain and occasionally or regularly consume alcohol. Furthermore, we found in tumour and margin samples from patients with concomitant diseases an association between SPRR1A and SPRR2A levels. Our results showed altered concentrations of SPRR1A at margins, depending on HPV status. : These results suggest that differences in SPRR proteins are determined by disease status and unhealthy behaviours, which, in a wider perspective, can influence carcinogenesis.

摘要

头颈部鳞状细胞癌（HNSCC）的发病率在全球排名第六。富含脯氨酸的小分子蛋白（SPRRs）是角质形成细胞包膜的前体，可作为转谷氨酰胺酶的底物。SPRR表达的变化是少数几种癌症的特征。我们的目的是测定61例HNSCC患者（口腔鳞状细胞癌、口咽鳞状细胞癌、喉鳞状细胞癌、下咽鳞状细胞癌、鼻旁窦鳞状细胞癌和涎腺鳞状细胞癌）肿瘤样本中SPRR1A和SPRR2A的浓度。此外，我们旨在确定蛋白质浓度与其他临床和/或人口统计学变量之间的关系。采用酶联免疫吸附测定（ELISA）试验来测定肿瘤组织匀浆中SPRR的浓度。在切缘样本中，我们发现SPRR1A水平与淋巴结状态（N）之间以及肿瘤和切缘中SPRR1A水平与G2组织学分级之间存在统计学显著关联。当我们分析烟草和酒精习惯的影响时，我们发现切缘样本中吸烟者和非吸烟者的SPRR1A和SPRR2A含量存在统计学显著差异。此外，我们发现从不饮酒、偶尔饮酒或经常饮酒的患者的肿瘤和切缘样本中，SPRR1A和SPRR2A水平存在统计学显著差异。此外，我们在患有合并症患者的肿瘤和切缘样本中发现了SPRR1A和SPRR2A水平之间的关联。我们的结果显示，切缘处SPRR1A的浓度根据人乳头瘤病毒（HPV）状态而改变。这些结果表明，SPRR蛋白的差异由疾病状态和不健康行为决定，从更广泛的角度来看，这些因素可能会影响致癌作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/25c28160bf34/diagnostics-15-01633-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/84292d632916/diagnostics-15-01633-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/065aef7b4e96/diagnostics-15-01633-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/6c02c2c3c5ba/diagnostics-15-01633-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/433caad57bff/diagnostics-15-01633-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/36c08c0c3138/diagnostics-15-01633-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/7cd1deb7ef04/diagnostics-15-01633-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/4c49eb3d5aee/diagnostics-15-01633-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/abf9522d0086/diagnostics-15-01633-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/25c28160bf34/diagnostics-15-01633-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/84292d632916/diagnostics-15-01633-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/065aef7b4e96/diagnostics-15-01633-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/6c02c2c3c5ba/diagnostics-15-01633-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/433caad57bff/diagnostics-15-01633-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/36c08c0c3138/diagnostics-15-01633-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/7cd1deb7ef04/diagnostics-15-01633-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/4c49eb3d5aee/diagnostics-15-01633-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/abf9522d0086/diagnostics-15-01633-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d28/12248949/25c28160bf34/diagnostics-15-01633-g009.jpg

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本文引用的文献

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Assessment of Concentration KRT6 Proteins in Tumor and Matching Surgical Margin from Patients with Head and Neck Squamous Cell Carcinoma.评估头颈部鳞状细胞癌患者肿瘤和匹配手术切缘中 KRT6 蛋白的浓度。
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Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients.与生存相关的指标 ALOX12B 和 SPRR1A 与 HPV16 阴性的头颈部鳞状细胞癌患者的 DNA 损伤修复和肿瘤微环境状态有关。
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