National Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Nat Commun. 2022 Sep 3;13(1):5190. doi: 10.1038/s41467-022-32814-y.
Preliminary evidence from China and other countries has suggested that coronavirus disease 2019 (COVID-19) mitigation measures have caused a decline in preterm births, but evidence is conflicting. Utilising a national representative data of 11,714,947 pregnant women in China, we explored the immediate changes in preterm birth rates during the COVID-19 mitigation period using an interrupted-time-series analysis. We defined the period prior to February 1, 2020 as the baseline, followed by the COVID-19 mitigation stage. In the first month of the COVID-19 mitigation, a significant absolute decrease in preterm birth rates of 0.68% (95%CI:-1.10% to -0.26%) in singleton, and of 2.80% (95%CI:-4.51% to -1.09%) in multiple births was noted. This immediate decline in Wuhan was greater than that at the national level among singleton births [-2.21% (95%CI:-4.09% to -0.34% vs. -0.68%)]. Here we report an immediate impact of COVID-19 mitigation measures on preterm birth in China.
来自中国和其他国家的初步证据表明，2019 年冠状病毒病（COVID-19）缓解措施导致早产率下降，但证据相互矛盾。利用中国 11714947 名孕妇的全国代表性数据，我们使用中断时间序列分析探讨了 COVID-19 缓解期间早产率的即时变化。我们将 2020 年 2 月 1 日之前的时期定义为基线，随后是 COVID-19 缓解阶段。在 COVID-19 缓解的第一个月，单胎妊娠的早产率显著绝对下降了 0.68%（95%CI：-1.10%至-0.26%），多胎妊娠的早产率下降了 2.80%（95%CI：-4.51%至-1.09%）。武汉的这一即时下降幅度大于单胎妊娠的全国水平[-2.21%（95%CI：-4.09%至-0.34%与-0.68%）]。在这里，我们报告了 COVID-19 缓解措施对中国早产的即时影响。
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