Department of Medical Genetics, Medical University Varna, Varna, Bulgaria.
Laboratory of Medical Genetics, St. Marina Hospital, Varna, Bulgaria.
Andrology. 2022 Nov;10(8):1484-1499. doi: 10.1111/andr.13287. Epub 2022 Sep 11.
The dynein-related genes may have a role in the etiology of male infertility, particularly in cases of impaired sperm motility.
The goal of this review is to compile a list of the most important dynein-related candidate genes that may contribute to male factor infertility.
Databases were searched using the keywords "dynein," "male," "infertility," and by applying strict inclusion criteria. A meta-analysis was also performed by using the eligible case-control studies. The odd ratios (ORs), the Z-test score, and the level of significance were determined using a fixed model with a p value of 0.05. Funnel plots were used to check for publication bias.
There were 35 studies that met the inclusion criteria. There were a total of 15 genes responsible for the production of dynein structural proteins, the production of dynein assembling factors, and potentially associated with male infertility. A total of five case-control studies were eligible for inclusion in the meta-analysis. Variants in the dynein-related genes were linked to an increased the risk of male infertility (OR = 21.52, 95% confidence interval 8.34-55.50, Z test = 6.35, p < 0.05). The percentage of heterogeneity, I , was 47.00%. The lack of variants in the dynein genes was an advantage, and this was statistically significant.
The results from the present review illustrate that pathogenic variants in genes both for dynein synthesis and for dynein assembly factors could be associated with isolated cases of male infertility without any other symptoms.
The genes addressed in this study, which are involved in both the production and assembly of dynein, could be used as molecular targets for future research into the etiology of sperm motility problems.
动力蛋白相关基因可能在男性不育的病因中起作用，尤其是在精子运动能力受损的情况下。
本综述的目的是列出可能导致男性因素不育的最重要的动力蛋白相关候选基因。
使用关键词“dynein”、“male”、“infertility”，并应用严格的纳入标准，在数据库中搜索。还通过合格的病例对照研究进行了荟萃分析。使用固定模型确定比值比 (OR)、Z 检验评分和显著性水平，p 值为 0.05。使用漏斗图检查发表偏倚。
有 35 项研究符合纳入标准。共有 15 个基因负责产生动力蛋白结构蛋白、产生动力蛋白组装因子，并可能与男性不育有关。共有 5 项病例对照研究符合纳入荟萃分析的标准。动力蛋白相关基因的变异与男性不育的风险增加相关（OR=21.52，95%置信区间 8.34-55.50，Z 检验=6.35，p<0.05）。异质性百分比，I，为 47.00%。缺乏动力蛋白基因的变异是一个优势，这在统计学上是显著的。
本综述的结果表明，动力蛋白合成和动力蛋白组装因子基因的致病性变异可能与没有其他症状的孤立男性不育病例有关。
本研究中涉及的参与动力蛋白产生和组装的基因可以作为未来研究精子运动问题病因的分子靶标。
