Parkes Rachel, Garcia Thomas X
Center for Drug Discovery, Baylor College of Medicine, Houston, USA.
Department of Pathology & Immunology, Baylor College of Medicine, Houston, USA.
Expert Rev Proteomics. 2024 Apr;21(4):181-203. doi: 10.1080/14789450.2024.2327553. Epub 2024 Apr 10.
Male infertility is a major public health concern globally. Proteomics has revolutionized our comprehension of male fertility by identifying potential infertility biomarkers and reproductive defects. Studies comparing sperm proteome with other male reproductive tissues have the potential to refine fertility diagnostics and guide infertility treatment development.
This review encapsulates literature using proteomic approaches to progress male reproductive biology. Our search methodology included systematic searches of databases such as PubMed, Scopus, and Web of Science for articles up to 2023. Keywords used included 'male fertility proteomics,' 'spermatozoa proteome,' 'testis proteomics,' 'epididymal proteomics,' and 'non-hormonal male contraception.' Inclusion criteria were robust experimental design, significant contributions to male fertility, and novel use of proteomic technologies.
Expert analysis shows a shift from traditional research to an integrative approach that clarifies male reproductive health's molecular intricacies. A gap exists between proteomic discoveries and clinical application. The expert opinions consolidated here not only navigate the current findings but also chart the future proteomic applications for scientific and clinical breakthroughs. We underscore the need for continued investment in proteomic research - both in the technological and collaborative arenas - to further unravel the secrets of male fertility, which will be central to resolving fertility issues in the coming era.
男性不育是全球主要的公共卫生问题。蛋白质组学通过识别潜在的不育生物标志物和生殖缺陷，彻底改变了我们对男性生育能力的理解。将精子蛋白质组与其他男性生殖组织进行比较的研究，有可能优化生育诊断并指导不育治疗的发展。
本综述总结了使用蛋白质组学方法推动男性生殖生物学发展的文献。我们的检索方法包括系统检索如PubMed、Scopus和Web of Science等数据库中截至2023年的文章。使用的关键词包括“男性生育蛋白质组学”、“精子蛋白质组”、“睾丸蛋白质组学”、“附睾蛋白质组学”和“非激素男性避孕”。纳入标准为稳健的实验设计、对男性生育能力的重大贡献以及蛋白质组学技术的新颖应用。
专家分析表明，研究正从传统研究转向综合方法，以阐明男性生殖健康的分子复杂性。蛋白质组学发现与临床应用之间存在差距。这里汇总的专家意见不仅梳理了当前的研究结果，还规划了蛋白质组学在未来实现科学和临床突破的应用方向。我们强调需要在蛋白质组学研究方面持续投入——包括技术和合作领域——以进一步揭开男性生育能力的秘密，这对于解决未来时代的生育问题至关重要。
