Choi Mihyun, Yoon Eun Gyu, Nam Ki Tae, Yun Cheolmin
Department of Ophthalmology, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, Korea.
Department of Ophthalmology, Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Seoul, Korea.
Int Ophthalmol. 2023 Mar;43(3):973-980. doi: 10.1007/s10792-022-02499-9. Epub 2022 Sep 4.
We sought to investigate the clinical features of eyes with unilateral type 3 macular neovascularization (MNV) according to the degenerative features of fellow eyes.
We retrospectively reviewed 55 patients with unilateral type 3 MNV and identified degenerative features including geographic atrophy (GA) in fellow eyes using multimodal imaging. Then, the clinical features of eyes with type 3 MNV at baseline and during follow-up with anti-vascular endothelial growth factor treatment and an as-needed regimen were compared according to the degenerative features of fellow eyes.
Eighteen patients (32.7%) had GA in fellow eyes; initial disease manifestations of type 3 MNV eyes including stage, best-corrected visual acuity, and choroidal thickness (CT) did not vary between groups (all P > 0.05). During follow-up, a rate of complete fluid resolution after three monthly loading injections was not associated with GA in fellow eyes (P = 0.703), while a lower rate of early recurrence within 3 months after loading treatment was associated with thinner CT in type 3 MNV eyes and GA over one disc area in fellow eyes (P = 0.025 and P = 0.021).
Degenerative features of fellow eyes in patients with unilateral type 3 MNV may be associated with the clinical characteristics of affected eyes.
我们旨在根据对侧眼的退行性特征，研究单侧3型黄斑新生血管（MNV）患眼的临床特征。
我们回顾性分析了55例单侧3型MNV患者，并使用多模态成像确定对侧眼中包括地图样萎缩（GA）在内的退行性特征。然后，根据对侧眼的退行性特征，比较3型MNV患眼在基线时以及接受抗血管内皮生长因子治疗和按需治疗方案随访期间的临床特征。
18例患者（32.7%）对侧眼有GA；3型MNV患眼的初始疾病表现，包括分期、最佳矫正视力和脉络膜厚度（CT），在两组之间无差异（所有P>0.05）。随访期间，三个月的负荷注射后完全液体消退率与对侧眼的GA无关（P=0.703），而负荷治疗后3个月内较低的早期复发率与3型MNV患眼较薄的CT以及对侧眼超过一个视盘面积的GA有关（P=0.025和P=0.021）。
单侧3型MNV患者对侧眼的退行性特征可能与患眼的临床特征有关。
