Department of Ophthalmology, Vienna Reading Center, Medical University of Vienna, Vienna, Austria ; and.
Department of Ophthalmology, Macula Clinic, Medical University of Vienna, Vienna, Austria .
Retina. 2022 Mar 1;42(3):485-493. doi: 10.1097/IAE.0000000000003330.
To explore the condition of fellow eyes of patients with macular neovascularization Type 3 (MNV3) and to verify whether the retinal-choroidal anastomosis (RCA) develops equally in all MNV types.
The contralateral eyes of 94 patients with MNV3, 96 patients with MNV1, and 96 patients with MNV2 were included. Multimodal imaging was performed. The MNV3 stage including the development of fibrosis and RCA over 24 months was determined.
In the contralateral eyes of patients of the solitary (one lesion) MNV3 group, 32 eyes (42.1%) showed early/intermediate age-related macular degeneration, 25 eyes (33%) showed MNV3, and 11 eyes (14.5%) experienced fibrosis, of which 4 eyes (5.2%) had a RCA, 7 eyes (9.2%) had atrophy after resolved MNV3, and 1 eye (1.3%) developed MNV1. In the multifocal (more than one lesion) MNV3 group, 2 eyes (11.1%) showed early/intermediate age-related macular degeneration, 9 eyes (50%) showed 15 MNV3 lesions, and 4 eyes (22.2%) showed fibrosis, of which 2 eyes (11.1%) manifested with a RCA and 3 eyes (16.7%) showed atrophy after resolved MNV3. The number of eyes with a RCA accounted for 40% of all eyes with fibrosis. The count of simultaneous bilateral multifocal MNV3 was 5 (55.6%). In the MNV1 and MNV2 groups, no eye developed a RCA. The incidence of RCAs in the scarred eyes in MNV3 was significantly higher (P < 0.0001).
Retinal-choroidal anastomosis is an exclusive clinical feature of MNV3. The development of the multifocal MNV3 is usually bilateral and simultaneous. The occurrence of fibrosis in MNV3 has decreased dramatically after the introduction of the antiangiogenic therapy.
探讨黄斑新生血管 3 型（MNV3）患者对侧眼的情况，并验证视网膜脉络膜吻合（RCA）是否在所有 MNV 类型中均等发展。
纳入 94 例 MNV3 患者、96 例 MNV1 患者和 96 例 MNV2 患者的对侧眼。进行多模态成像。确定 24 个月内 MNV3 分期的纤维化和 RCA 发展情况。
在孤立性（单发病变）MNV3 组患者的对侧眼中，32 只眼（42.1%）表现为早期/中期年龄相关性黄斑变性，25 只眼（33%）表现为 MNV3，11 只眼（14.5%）出现纤维化，其中 4 只眼（5.2%）出现 RCA，7 只眼（9.2%）在 MNV3 消退后出现萎缩，1 只眼（1.3%）出现 MNV1。在多灶性（多个病变）MNV3 组中，2 只眼（11.1%）表现为早期/中期年龄相关性黄斑变性，9 只眼（50%）表现为 15 个 MNV3 病变，4 只眼（22.2%）出现纤维化，其中 2 只眼（11.1%）出现 RCA，3 只眼（16.7%）在 MNV3 消退后出现萎缩。出现 RCA 的眼数占所有纤维化眼的 40%。同时双侧多灶性 MNV3 的计数为 5（55.6%）。在 MNV1 和 MNV2 组中，无一眼出现 RCA。MNV3 瘢痕眼中 RCA 的发生率明显更高（P < 0.0001）。
视网膜脉络膜吻合是 MNV3 的特有临床特征。多灶性 MNV3 的发展通常是双侧和同时发生的。抗血管生成治疗引入后，MNV3 中的纤维化明显减少。
