Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznan, Poland.
Department of Trace Analysis, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
J Trace Elem Med Biol. 2022 Dec;74:127064. doi: 10.1016/j.jtemb.2022.127064. Epub 2022 Aug 29.
Coronary artery disease possess inflammatory background related to enzymatic processes with trace elements involvements as co-factors. The aim of the study was to compare serum, urine and salivary copper, magnesium, calcium and zinc levels with inflammatory indices obtained from the whole blood count in patients with complex coronary artery disease.
Fifty-two (42(81 %) males, 10 (19 %) females) consecutive patients (mean (SD) age 68 (9) years with symptomatic complex coronary artery disease were enrolled into prospective single center study in 2021. Serum, saliva and urine samples were collected at the day of admission for trace elements concentration (copper, zinc, magnesium, calcium) and compared with inflammatory indexes obtained from preoperative and perioperative period.
Multivariable regression analysis revealed relation between the copper serum concentration and neutrophil to lymphocyte ratio (NLR) and systemic inflammatory index (SII).
Serum copper concentration interplay with preoperative inflammatory activation in complex coronary disease measured by NLR and SII. The copper serum concentration possesses the strongest relation to preoperative inflammatory activation in patients reffered for off-pump coronary artery bypass grafting.
冠心病具有与酶促过程相关的炎症背景，微量元素作为辅助因子参与其中。本研究旨在比较复杂冠心病患者的血清、尿液和唾液中的铜、镁、钙和锌水平与全血细胞计数得出的炎症指标。
2021 年，我们纳入了 52 名（42 名男性[81%]，10 名女性[19%]）连续就诊的有症状的复杂冠心病患者（平均年龄为 68[9]岁）进行前瞻性单中心研究。在入院当天采集血清、唾液和尿液样本，用于检测微量元素浓度（铜、锌、镁、钙），并与术前和围手术期获得的炎症指标进行比较。
多变量回归分析显示，血清铜浓度与中性粒细胞与淋巴细胞比值（NLR）和全身炎症指数（SII）之间存在关系。
血清铜浓度与复杂冠心病患者术前炎症激活相互作用，通过 NLR 和 SII 来衡量。在接受非体外循环冠状动脉旁路移植术的患者中，血清铜浓度与术前炎症激活的关系最强。
