Urbanowicz Tomasz, Hanć Anetta, Olasińska-Wiśniewska Anna, Komosa Anna, Filipiak Krzysztof J, Radziemski Artur, Matejuk Mateusz, Uruski Paweł, Tykarski Andrzej, Jemielity Marek
Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Department of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Rev Cardiovasc Med. 2023 Dec 25;24(12):358. doi: 10.31083/j.rcm2412358. eCollection 2023 Dec.
Coronary artery atherosclerosis development and progression are related to generic, clinical, and lifestyle factors combined with inflammatory activation. The relationship between trace element concentration and morbidity is under investigation to gain a clearer understanding of underlying pathological processes.
Thirty-five consecutive patients (22 males and 13 females) with a median [interquartile range (IQR)] age of 67 (61-73) years presenting with anginal symptoms were included in the single center prospective analysis in 2022 and divided into a epicardial coronary artery disease (CAD) and non-CAD group. Scalp hair chemical analysis and inflammatory markers from a peripheral blood count were analyzed.
The correlation analysis of elements and inflammatory indexes showed statistical significance between median hair lithium (Li) concentration and the systemic inflammatory index (SII) (r = -0.476, = 0.046), antimony (Sb) (r = -0.521, = 0.028) followed by chromium (Cr) (r = -0.478, = 0.045) and iron (Fe) (r = -0.604, = 0.008) in the CAD group. Similar correlations were not found in non-CAD group.
The correlation between scalp hair lithium (Li), antimony (Sb), chromium (Cr) and iron (Fe) concentration and the systemic inflammatory index (SII) were revealed only in patients with coronary artery disease. Our analysis identified a strong correlation between inflammatory activation and iron concentration.
冠状动脉粥样硬化的发生和发展与遗传、临床和生活方式因素以及炎症激活有关。微量元素浓度与发病率之间的关系正在研究中，以便更清楚地了解潜在的病理过程。
2022年，35例连续出现心绞痛症状的患者（22例男性和13例女性）被纳入单中心前瞻性分析，年龄中位数[四分位间距（IQR）]为67（61-73）岁，并分为心外膜冠状动脉疾病（CAD）组和非CAD组。分析了头皮毛发化学分析结果和外周血细胞计数中的炎症标志物。
元素与炎症指标的相关性分析显示，CAD组中毛发锂（Li）浓度中位数与全身炎症指标（SII）之间具有统计学意义（r = -0.476，P = 0.046），其次是锑（Sb）（r = -0.521，P = 0.028）、铬（Cr）（r = -0.478，P = 0.045）和铁（Fe）（r = -0.604，P = 0.008）。在非CAD组中未发现类似的相关性。
仅在冠状动脉疾病患者中发现头皮毛发锂（Li）、锑（Sb）、铬（Cr）和铁（Fe）浓度与全身炎症指标（SII）之间存在相关性。我们的分析确定了炎症激活与铁浓度之间存在强相关性。
