Am Rev Respir Dis. 1987 Jul;136(1):225-44. doi: 10.1164/ajrccm/136.1.225.
Chronic obstructive pulmonary disease (COPD) and asthma are the major causes of pulmonary disability in the United States, with at least 10 million Americans suffering form COPD and up to 5% of the population afflicted with asthma. Over the past 20 years, major strides have been made in our understanding of the pathophysiology of these disorders, although there are still large gaps in our knowledge. While a number of position papers and statements have been promulgated by the American Thoracic Society concerning various aspects of the diagnosis and treatment of COPD and asthma, it was felt that a review of the overall topic was timely. This statement represents the combined efforts of a Task Group appointed by the Scientific Assemble of Clinical Problems of the American Thoracic Society to accomplish this task. Clearly, we could not cover every aspect of this broad topic nor even provide a detailed review of those areas addressed. We elected instead to concentrate on clinically relevant topics and to provide sufficient data to be useful as a guide as well as to include selected, but in no was exhaustive, references. The first two chapters define the entities and set forth recommendations for diagnosis, hospital admission, and discharge. The remaining four chapters critically review the various facets of therapy. We have noted controversial areas and those were conclusive experimental data are not yet available. In these situations, the committee often decided to take a position on one side or the other based upon the best available information.
慢性阻塞性肺疾病(COPD)和哮喘是美国肺部残疾的主要原因,至少有1000万美国人患有COPD,高达5%的人口患有哮喘。在过去20年里,我们对这些疾病病理生理学的理解取得了重大进展,尽管在知识方面仍存在很大差距。虽然美国胸科学会已经发布了一些关于COPD和哮喘诊断与治疗各个方面的立场文件和声明,但认为对整个主题进行一次综述是及时的。本声明代表了美国胸科学会临床问题科学大会任命的一个任务组为完成这项任务而做出的共同努力。显然,我们无法涵盖这个广泛主题的每个方面,甚至无法对所涉及的领域进行详细综述。相反,我们选择专注于临床相关主题,并提供足够的数据作为有用的指南,同时纳入一些选定的参考文献,但并非详尽无遗。前两章定义了这些疾病,并提出了诊断、住院和出院的建议。其余四章对治疗的各个方面进行了批判性综述。我们指出了有争议的领域,以及尚无确凿实验数据的领域。在这些情况下,委员会通常根据现有最佳信息在某一方采取立场。