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生物医学领域中的量子点:一种适用于多种应用场景的智能先进纳米载体。

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application.

作者信息

Singh Siddharth, Raina Deepika, Rishipathak Dinesh, Babu Kamesh R, Khurana Riya, Gupta Yogesh, Garg Kartik, Rehan Farah, Gupta Shraddha M

机构信息

Department of Pharmaceutical Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India.

School of Pharmacy, Graphic era hill University, Dehradun, Uttarakhand, India.

出版信息

Arch Pharm (Weinheim). 2022 Dec;355(12):e2200299. doi: 10.1002/ardp.202200299. Epub 2022 Sep 4.

Abstract

Quantum dots (QDs) are semiconducting nanoparticles having different optical and electrical properties when compared to larger particles. They exhibit photoluminescence when irradiated with ultraviolet light, which is due to the transition of an excited electron from the valence band to the conductance band followed by the return of the exciting electron back into the valence band. The size and material of QDs can affect their optical and other properties too. The QDs possess special attributes like high brightness, protection from photobleaching, photostability, color tunability, low toxicity, low production cost, a multiplexing limit, and a high surface-to-volume proportion, which make them a promising tool for biomedical applications. Here, in this study, we summarize the utilization of QDs in different applications including bioimaging, diagnostics, immunostaining, single-cell analysis, drug delivery, and protein detection. Moreover, we discuss the advantages and challenges of using QDs in biomedical applications when compared with other conventional tools.

摘要

量子点(QDs)是一种半导体纳米颗粒,与较大的颗粒相比,具有不同的光学和电学性质。当受到紫外光照射时,它们会表现出光致发光现象,这是由于受激电子从价带跃迁到导带,随后受激电子返回价带所致。量子点的尺寸和材料也会影响其光学和其他性质。量子点具有高亮度、抗光漂白、光稳定性、颜色可调性、低毒性、低成本生产、多重检测极限以及高表面积与体积比等特殊属性,这些特性使其成为生物医学应用中一种很有前景的工具。在此项研究中,我们总结了量子点在不同应用中的利用情况,包括生物成像、诊断、免疫染色、单细胞分析、药物递送和蛋白质检测。此外,我们还讨论了与其他传统工具相比,在生物医学应用中使用量子点的优势和挑战。

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