Shen J S, Xu Y A
Department of Emergency, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322014, China.
Department of Emergency, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Aug 20;38(8):794-798. doi: 10.3760/cma.j.cn501120-20210517-00191.
Sweat glands are widely distributed in human skin, among which eccrine sweat glands play major roles in heat dissipation and sweat secretion. Sweat secretion is mainly regulated by nervous system and includes two processes of secretion of secretory coil and reabsorption of sweat duct, involving various ion channels and proteins such as calcium ion channel, potassium ion channel, sodium-potassium-chloride co-transporter 1, Best2 protein, aquaporin 5, cystic fibrosis transmembrane conductance regulator, and epithelial sodium ion channel. This paper reviews the nerve conduction system and various ion channels involved in sweat secretion of exocrine sweat glands in order to provide a theoretical basis for the study of regeneration, repair, and transformation of stem cells.
汗腺广泛分布于人体皮肤，其中外泌汗腺在散热和汗液分泌中起主要作用。汗液分泌主要受神经系统调节，包括分泌盘的分泌和汗腺导管的重吸收两个过程，涉及多种离子通道和蛋白质，如钙离子通道、钾离子通道、钠-钾-氯共转运蛋白1、Best2蛋白、水通道蛋白5、囊性纤维化跨膜传导调节因子和上皮钠离子通道。本文对外泌汗腺汗液分泌所涉及的神经传导系统及各种离子通道进行综述，以期为干细胞的再生、修复及转化研究提供理论依据。
