[影响汗腺发育的信号通路及其在体外汗腺腺样细胞重建中的作用研究进展]
[Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro].
作者信息
Lang D H, Ba T, Cao S J, Li F, Dong H, Li J L, Wang L F
机构信息
The Third Clinical Medical College of Inner Mongolia Medical University, Hohhot 010110, China.
Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Feb 20;38(2):195-200. doi: 10.3760/cma.j.cn501120-20201020-00442.
The damage of sweat glands in patients with extensive deep burns results in the loss of thermoregulation, which seriously affects the quality of life of patients. At present, there are many researches on the repair of sweat gland function, but the mechanism of human sweat gland development has not been fully clarified. More and more studies have shown that the cascaded pathways of Wnt/β-catenin, ecto- dysplasin A/ectodysplasin A receptor/nuclear factor-κB, sonic hedgehog, and forkhead box transcription factor jointly affect the development of sweat glands, and it has been reported that the cascaded signaling pathways can be used to achieve the reconstruction of sweat adenoid cells in vitro. This article reviews the signaling pathways that affect the development of sweat glands and their involvement in the reconstruction of sweat adenoid cells in vitro.
大面积深度烧伤患者的汗腺损伤会导致体温调节功能丧失，严重影响患者的生活质量。目前，关于汗腺功能修复的研究有很多，但人类汗腺发育的机制尚未完全阐明。越来越多的研究表明，Wnt/β-连环蛋白、外胚层发育不良蛋白A/外胚层发育不良蛋白A受体/核因子-κB、音猬因子和叉头框转录因子的级联途径共同影响汗腺的发育，并且有报道称这些级联信号通路可用于在体外实现汗腺细胞的重建。本文综述了影响汗腺发育的信号通路及其在体外汗腺细胞重建中的作用。
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