具核梭杆菌，结直肠癌的关键致病因子和微生物生物标志物。
Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer.
机构信息
Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China; NHC Key Laboratory of Digestive Diseases, Shanghai Jiao Tong University, Shanghai, China; State Key Laboratory for Oncogenes and Related Genes, Shanghai Jiao Tong University, Shanghai, China; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China; NHC Key Laboratory of Digestive Diseases, Shanghai Jiao Tong University, Shanghai, China; State Key Laboratory for Oncogenes and Related Genes, Shanghai Jiao Tong University, Shanghai, China; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Trends Microbiol. 2023 Feb;31(2):159-172. doi: 10.1016/j.tim.2022.08.010. Epub 2022 Sep 1.
Colorectal cancer (CRC), one of the most prevalent cancers, has complex etiology. The dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC. Fusobacterium nucleatum, an oral anaerobic opportunistic pathogen, is enriched in both stools and tumor tissues of patients with CRC. Therefore, F. nucleatum is considered to be a risk factor for CRC. This review summarizes the biological characteristics and the mechanisms underlying the regulatory behavior of F. nucleatum in the tumorigenesis and progression of CRC. F. nucleatum as a marker for the early warning and prognostic prediction of CRC, and as a target for prevention and treatment, is also described.
结直肠癌（CRC）是最常见的癌症之一，其病因复杂。肠道细菌失调已被强调为 CRC 的一个重要致病因素。具核梭杆菌是一种口腔厌氧机会致病菌，在 CRC 患者的粪便和肿瘤组织中均有富集。因此，具核梭杆菌被认为是 CRC 的一个危险因素。本综述总结了具核梭杆菌在 CRC 发生发展中的生物学特性及其调控行为的机制。还描述了具核梭杆菌作为 CRC 早期预警和预后预测的标志物，以及作为预防和治疗靶点的可能性。
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