线粒体靶向金属铱（III）配合物用于 HS 响应性细胞内氧化还原调控的高效光氧化抗癌剂。
Mitochondria-targeted cyclometalated iridium (III) complex for HS-responsive intracellular redox regulation as potent photo-oxidation anticancer agent.
机构信息
Key Laboratory of Theoretical Organic Chemistry and Function Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 411201, China.
Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
出版信息
J Biol Inorg Chem. 2022 Oct;27(7):641-651. doi: 10.1007/s00775-022-01957-0. Epub 2022 Sep 4.
Owing to the safety and low toxicity, photodynamic therapy (PDT) for cancer treatment has received extensive attention. However, the excess HS in cancer cells reduces the PDT efficiency, because HS indirectly depletes the reactive oxygen species (ROS). To improve anticancer efficiency, a mitochondria-targeted iridium(III) complex Ir-MMB has been developed as HS consumer and photo-oxidation anticancer agent. On the one hand, complex Ir-MMB can consume HS with sensitive phosphorescence turn-on, which has been successfully applied to exogenous and endogenous HS response imaging in living cells. On the other hand, Ir-MMB can enhance its anticancer activity and cause photo-oxidation damage via catalyzing the oxidation of reduced form of nicotinamide-adenine dinucleotide (NADH) to NAD and producing HO under light, and ultimately results in cell apoptosis through mitochondrial depolarization and ROS production.
由于其安全性和低毒性，光动力疗法（PDT）在癌症治疗中受到广泛关注。然而，癌细胞中过多的 HS 会降低 PDT 效率，因为 HS 会间接耗尽活性氧（ROS）。为了提高抗癌效率，已经开发出一种靶向线粒体的铱（III）配合物 Ir-MMB 作为 HS 消耗剂和光氧化抗癌剂。一方面，配合物 Ir-MMB 可以通过敏感的磷光开启来消耗 HS，这已成功应用于活细胞中外源和内源性 HS 响应成像。另一方面，Ir-MMB 可以通过在光照下催化还原型烟酰胺腺嘌呤二核苷酸（NADH）氧化为 NAD 并产生 HO 来增强其抗癌活性并引起光氧化损伤，最终通过线粒体去极化和 ROS 产生导致细胞凋亡。
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