M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Bull Exp Biol Med. 2022 Aug;173(4):429-432. doi: 10.1007/s10517-022-05580-6. Epub 2022 Sep 5.
The features of individual fragments of IgA1 protease of Neisseria meningitidis serogroup B during the formation of immunity to bacterial infections in animals and humans were studied. The antibodies to the immunogenic regions of the studied proteins are also detected in mice infected with some bacterial pathogens and in humans with bacterial meningitis. A region of IgA1 protease was identified that is not capable of producing antibodies during immunization of animals, but that detects homologous antibodies in the blood of humans and animals recovered from bacterial infections. It has been suggested that this fragment plays a regulatory role in the process of immunogenesis.
研究了 B 群脑膜炎奈瑟菌 IgA1 蛋白酶的各个片段在动物和人类对细菌感染形成免疫中的特征。在感染某些细菌病原体的小鼠和患有细菌性脑膜炎的人类中，也检测到针对研究蛋白免疫原性区域的抗体。鉴定出 IgA1 蛋白酶的一个区域，该区域在动物免疫接种过程中不能产生抗体，但在从细菌感染中恢复的人和动物的血液中检测到同源抗体。有人提出，该片段在免疫发生过程中起调节作用。
