Kabakov A V, Lykov A P, Morozov D V, Kazakov O V, Poveshchenko A F, Raiter T V, Strunkin D N, Konenkov V I
Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
Bull Exp Biol Med. 2017 Aug;163(4):490-492. doi: 10.1007/s10517-017-3835-6. Epub 2017 Aug 29.
The histological and immunohistochemical type of chemically induced (injection of N-methyl-N-nitrosourea into the mammary gland) breast tumor was studied in Wistar females. The tumor induced by N-methyl-N-nitrosourea was moderately differentiated adenocarcinoma with infiltrative growth lacking estrogen-α and human epidermal growth factor receptors, and expressing progesterone receptors; tumor cells were characterized by high proliferative activity. This variant of chemically induced breast tumor corresponds to human breast cancer luminal type B.
在Wistar雌性大鼠中研究了化学诱导（向乳腺注射N-甲基-N-亚硝基脲）的乳腺肿瘤的组织学和免疫组织化学类型。N-甲基-N-亚硝基脲诱导的肿瘤为中度分化腺癌，呈浸润性生长，缺乏雌激素-α和人表皮生长因子受体，表达孕激素受体；肿瘤细胞具有高增殖活性。这种化学诱导的乳腺肿瘤变体对应于人类乳腺癌管腔B型。
