Affiliated Hospital of Guangdong Medical University and Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University, Zhanjiang, 524001, China.
Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Cell Mol Life Sci. 2022 Sep 4;79(9):506. doi: 10.1007/s00018-022-04534-5.
Scoliosis is a common spinal deformity that considerably affects the physical and psychological health of patients. Studies have shown that genetic factors play an important role in scoliosis. However, its etiopathogenesis remain unclear, partially because of the genetic heterogeneity of scoliosis and the lack of appropriate model systems. Recently, the development of efficient gene editing methods and high-throughput sequencing technology has made it possible to explore the underlying pathological mechanisms of scoliosis. Owing to their susceptibility for developing scoliosis and high genetic homology with human, zebrafish are increasingly being used as a model for scoliosis in developmental biology, genetics, and clinical medicine. Here, we summarize the recent advances in scoliosis research on zebrafish and discuss the prospects of using zebrafish as a scoliosis model.
脊柱侧凸是一种常见的脊柱畸形，严重影响患者的身心健康。研究表明，遗传因素在脊柱侧凸中起重要作用。然而，其发病机制尚不清楚，部分原因是脊柱侧凸的遗传异质性和缺乏合适的模型系统。最近，高效基因编辑方法和高通量测序技术的发展使得探索脊柱侧凸的潜在病理机制成为可能。由于斑马鱼易发生脊柱侧凸，且与人类的遗传同源性高，因此它们在发育生物学、遗传学和临床医学中越来越多地被用作脊柱侧凸的模型。在这里，我们总结了斑马鱼脊柱侧凸研究的最新进展，并讨论了将斑马鱼用作脊柱侧凸模型的前景。
