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巨大左心室血栓导致双侧大脑后动脉卒中:一例报告并文献复习

Massive Left Ventricular Thrombus Causing Bilateral Posterior Cerebral Artery Stroke: A Case Report and Review of Literature.

作者信息

Jain Ashali, Haider Asad, Jones Tyler S

机构信息

Internal Medicine, University of Central Florida College of Medicine/HCA Florida North Florida Hospital, Gainesville, USA.

出版信息

Cureus. 2022 Aug 1;14(8):e27585. doi: 10.7759/cureus.27585. eCollection 2022 Aug.

DOI:10.7759/cureus.27585
PMID:36059347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9433785/
Abstract

Left ventricular thrombus (LVT) is a major complication of acute myocardial infarction (MI). Here, we describe the case of a 36-year-old female with a history of acute anterior MI six years prior to hospitalization, who presented with bilateral vision loss due to a bilateral embolic posterior cerebral artery (PCA) stroke in the setting of a 5.7 x 1.7 cm LVT. She underwent bilateral PCA thrombectomy, which led to improvement of her symptoms. Her LVT was managed non-surgically with apixaban and clopidogrel. Her case highlights the need for more medical education about LVT, as quick initiation of anticoagulation is essential in improving outcomes. We review the existing literature to explain the pathogenesis, diagnosis, and treatment of LVT.

摘要

左心室血栓(LVT)是急性心肌梗死(MI)的主要并发症。在此,我们描述一例36岁女性病例,该患者在住院前6年有急性前壁心肌梗死病史,因5.7×1.7 cm左心室血栓导致双侧大脑后动脉(PCA)栓塞性卒中而出现双侧视力丧失。她接受了双侧大脑后动脉取栓术,症状得到改善。她的左心室血栓采用阿哌沙班和氯吡格雷进行非手术治疗。她的病例凸显了对左心室血栓进行更多医学教育的必要性,因为迅速启动抗凝治疗对于改善预后至关重要。我们回顾现有文献以解释左心室血栓的发病机制、诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74e/9433785/2fb1c5abb526/cureus-0014-00000027585-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74e/9433785/afeb1c9247f7/cureus-0014-00000027585-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74e/9433785/2fb1c5abb526/cureus-0014-00000027585-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74e/9433785/afeb1c9247f7/cureus-0014-00000027585-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74e/9433785/2fb1c5abb526/cureus-0014-00000027585-i02.jpg

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本文引用的文献

1
Left Ventricular Thrombus Following Acute Myocardial Infarction: JACC State-of-the-Art Review.急性心肌梗死后左心室血栓:美国心脏病学会最新综述。
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Direct oral anticoagulants versus vitamin K antagonists for patients with left ventricular thrombus.直接口服抗凝剂与维生素 K 拮抗剂治疗左心室血栓患者的比较。
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直接口服抗凝剂和维生素 K 拮抗剂治疗左心室血栓的疗效:系统评价和荟萃分析。
PLoS One. 2021 Jul 26;16(7):e0255280. doi: 10.1371/journal.pone.0255280. eCollection 2021.
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Left Ventricular Thrombi: Insights from Cardiac Magnetic Resonance Imaging.左心室血栓:心脏磁共振成像的新视角。
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Efficacy and Safety of Direct Oral Anticoagulants Versus Vitamin K Antagonists in the Treatment of Left Ventricular Thrombus: A Systematic Review and Meta-analysis.直接口服抗凝剂与维生素 K 拮抗剂治疗左心室血栓的疗效和安全性:系统评价和荟萃分析。
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Warfarin versus direct oral anticoagulants for treating left ventricular thrombus: a systematic review and meta-analysis.华法林与直接口服抗凝剂治疗左心室血栓的系统评价和荟萃分析。
Thromb J. 2021 Feb 1;19(1):7. doi: 10.1186/s12959-021-00259-w.
7
Predictive Value of Cardiac CTA, Cardiac MRI, and Transthoracic Echocardiography for Cardioembolic Stroke Recurrence.心脏 CT 血管造影、心脏 MRI 和经胸超声心动图对心源性卒中复发的预测价值。
AJR Am J Roentgenol. 2021 Aug;217(2):336-346. doi: 10.2214/AJR.20.23903. Epub 2021 Jun 16.
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Use of Transthoracic Echocardiogram to Detect Left Ventricular Thrombi.经胸超声心动图检测左心室血栓。
Ann Thorac Surg. 2021 Feb;111(2):556-560. doi: 10.1016/j.athoracsur.2020.05.106. Epub 2020 Jul 17.
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Direct Oral Anticoagulants: A Quick Guide.直接口服抗凝剂:快速指南
Eur Cardiol. 2017 Aug;12(1):40-45. doi: 10.15420/ecr.2017:11:2.
10
Left Ventricular Thrombus After Acute Myocardial Infarction: Screening, Prevention, and Treatment.急性心肌梗死后左心室血栓:筛查、预防和治疗。
JAMA Cardiol. 2018 Jul 1;3(7):642-649. doi: 10.1001/jamacardio.2018.1086.