Department of General Surgery, Changsha Hospital Affiliated to Hunan Normal University/The Fourth Hospital of Changsha, Changsha, China.
Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Immunol. 2022 Aug 19;13:937565. doi: 10.3389/fimmu.2022.937565. eCollection 2022.
NETs are chromatin-derived webs extruded from neutrophils as a result of either infection or sterile stimulation using chemicals, cytokines, or microbes. In addition to the classical role that NETs play in innate immunity against infection and injuries, NETs have been implicated extensively in cancer progression, metastatic dissemination, and therapy resistance. The purpose of this review is to describe recent investigations into NETs and the roles they play in tumor biology and to explore their potential as therapeutic targets in cancer treatment.
NETs 是由中性粒细胞挤出的染色质衍生的网，是由感染或使用化学物质、细胞因子或微生物进行无菌刺激引起的。除了 NETs 在针对感染和损伤的先天免疫中发挥的经典作用外，NETs 还广泛涉及癌症进展、转移扩散和治疗耐药性。本文的目的是描述最近对 NETs 的研究及其在肿瘤生物学中的作用，并探讨它们作为癌症治疗中治疗靶点的潜力。
