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人上皮组织固有记忆调节性 T 细胞的特征。

Characterization of human epithelial resident memory regulatory T cells.

机构信息

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

出版信息

Front Immunol. 2022 Aug 19;13:962167. doi: 10.3389/fimmu.2022.962167. eCollection 2022.

DOI:10.3389/fimmu.2022.962167
PMID:36059538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9437974/
Abstract

Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin. Considering that thick dermis contains more Tregs than thin epidermis, the current understanding of skin Tregs might be biased toward dermal Tregs. Therefore, we sought to determine the phenotype and function of human epidermal and epithelial Tregs. Human epidermis and epithelium were allowed to float on a medium without adding any exogenous cytokines and stimulations for two days and then emigrants from the explants were analyzed. Foxp3 was selectively expressed in CD4CD103 T cells in the various human epithelia, as it is highly demethylated. CD4CD103Foxp3 cells suppressed proliferation of other resident memory T cells. The generation and maintenance of epithelial Tregs were independent of hair density and Langerhans cells. Collectively, immune-suppressive CD4CD103Foxp3 Tregs are present in the normal, noninflamed human epidermis and mucosal epithelia.

摘要

人类常驻记忆调节性 T 细胞（Tregs）存在于正常非炎症皮肤中。除了一个之外，之前所有的研究都使用全层人皮肤分析皮肤 Tregs。考虑到厚真皮比薄表皮含有更多的 Tregs，目前对皮肤 Tregs 的理解可能偏向于真皮 Tregs。因此，我们试图确定人类表皮和上皮 Tregs 的表型和功能。将人类表皮和上皮在没有添加任何外源性细胞因子和刺激物的培养基上漂浮两天，然后分析从外植体中迁移出的细胞。Foxp3 在各种人上皮中的 CD4CD103 T 细胞中选择性表达，因为它高度去甲基化。CD4CD103Foxp3 细胞抑制其他常驻记忆 T 细胞的增殖。上皮 Tregs 的产生和维持与毛发密度和朗格汉斯细胞无关。总之，免疫抑制性 CD4CD103Foxp3 Tregs 存在于正常非炎症的人类表皮和黏膜上皮中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/4669d1dc367e/fimmu-13-962167-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/38bc8bbb888f/fimmu-13-962167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/9c071ea156a3/fimmu-13-962167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/e3b254bdd688/fimmu-13-962167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/60bd6992971f/fimmu-13-962167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/f7479ddcd57b/fimmu-13-962167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/04b1fac293d2/fimmu-13-962167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/4669d1dc367e/fimmu-13-962167-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/38bc8bbb888f/fimmu-13-962167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/9c071ea156a3/fimmu-13-962167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/e3b254bdd688/fimmu-13-962167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/60bd6992971f/fimmu-13-962167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/f7479ddcd57b/fimmu-13-962167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/04b1fac293d2/fimmu-13-962167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5976/9437974/4669d1dc367e/fimmu-13-962167-g007.jpg

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4
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