人真皮不同网状层中真皮驻留记忆T细胞的数量、表型和功能差异。
Numerical, phenotypic and functional differences in human dermal resident memory T cells between reticular dermal layers.
作者信息
Sato Takuya, Asakawa Riko, Ogawa Youichi, Nagasaka Yuka, Kinoshita Manao, Shimada Shinji, Momosawa Akira, Kawamura Tatsuyoshi
机构信息
Department of Dermatology Faculty of Medicine University of Yamanashi Yamanashi Japan.
Department of Plastic Surgery Faculty of Medicine University of Yamanashi Yamanashi Japan.
出版信息
Skin Health Dis. 2024 Dec 1;4(6):e457. doi: 10.1002/ski2.457. eCollection 2024 Dec.
BACKGROUND
Resident memory T (T) cells and immunosuppressive Foxp3-expressing regulatory T (regT) cells are present in healthy, non-inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with the dermis being much thicker than the epidermis. However, it is unclear if T and regT cells differ between reticular dermal layers in terms of number, function or characteristics.
METHODS
This study examined numerical, phenotypic and functional differences in T and regT cells between the upper and lower reticular dermis in healthy, non-inflamed human skin using flow cytometry.
RESULTS
The phenotype and cytokine expressions of both types of cells were similar between reticular dermal layers. However, the cell count of both T and regT cells was significantly higher in the upper reticular dermis than in the lower reticular dermis.
CONCLUSIONS
T and regT cells are phenotypically and functionally identical between reticular dermal layers. However, both types of cells are more abundant in the upper reticular dermis.
背景
驻留记忆T（T）细胞和表达免疫抑制性叉头框蛋白3（Foxp3）的调节性T（regT）细胞存在于健康、未发炎和发炎的人类皮肤中。这两种类型的细胞在表皮和真皮中均有发现，其中真皮比表皮厚得多。然而，尚不清楚T细胞和regT细胞在网状真皮层之间在数量、功能或特征方面是否存在差异。
方法
本研究使用流式细胞术检测了健康、未发炎人类皮肤中上部和下部网状真皮之间T细胞和regT细胞的数量、表型和功能差异。
结果
两种类型细胞的表型和细胞因子表达在网状真皮层之间相似。然而，上部网状真皮中T细胞和regT细胞的细胞计数均显著高于下部网状真皮。
结论
T细胞和regT细胞在网状真皮层之间表型和功能相同。然而，这两种类型的细胞在上部网状真皮中更为丰富。
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