Grotting J C, Bunkis J, Vasconez L O
Ann Plast Surg. 1987 Jun;18(6):527-32. doi: 10.1097/00000637-198706000-00012.
The development of squamous cell carcinoma in pressure sores is a rare event, considering the high incidence of pressure sores within the elderly and paraplegic populations. The clinical courses of 10 patients with pressure sore carcinoma have been reviewed. The presence of a velvety, cauliflower-like growth on the surface of a long-standing pressure sore should alert the surgeon to the possibility of malignant degeneration. Most of these tumors are well-differentiated squamous cell carcinomas. Of the 10 patients, 8 (80%) died from massive local recurrence or distant metastases an average of 17 months after resection and flap closure despite having apparently localized disease. One patient was disease free when lost to follow-up at 2 years, and 1 patient is without evidence of recurrence or metastases 3 months postoperatively. Altered immunocompetence may play a role in the rapid progression and high mortality associated with this tumor after surgical manipulation.
考虑到压疮在老年人和截瘫人群中的高发病率，压疮发展为鳞状细胞癌是一种罕见事件。本文回顾了10例压疮癌患者的临床病程。长期存在的压疮表面出现天鹅绒样、菜花样生长应提醒外科医生警惕恶性变的可能性。这些肿瘤大多为高分化鳞状细胞癌。10例患者中，8例（80%）尽管疾病看似局限，但在切除及皮瓣闭合术后平均17个月死于大量局部复发或远处转移。1例患者在2年随访失访时无疾病，1例患者术后3个月无复发或转移迹象。免疫能力改变可能在手术操作后该肿瘤的快速进展和高死亡率中起作用。
