Sadegh Fazeli Mohammad, Lebaschi Amir Hosein, Hajirostam Morvarid, Keramati Mohammad Reza
Associate Professor of Surgery, Department of Surgery, Imam medical complex, Tehran University of Medical Sciences, Tehran, Iran.
General Surgeon, Department of Surgery, Imam medical complex, Tehran University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2013 Nov;27(4):215-24.
Marjolin's ulcer is a rare, aggressive condition that arises on chronic skin lesions and diseases. Inthis article, we will report 83 cases of this disease.
Retrospectively, we retrieved 83 records of patients with cancer arising from chronic skin conditions.Data concerning demography, type of original skin insult, time interval between original lesion and cancer,cancer histology, and lymph node involvement were recorded.
The mean age was 55.30 years (range: 21-90). There were 51 males (61.5%) and 32 females (38.5%).Foot was the most prevalent site of primary skin lesion (49.4%) followed by scalp (15.6%). Original skin insultswere burn (87.9%), osteomyelitis (2.4%), radiation (2.4%), electrical burn (1.2%), surgical scar (2.4%),pemphigus (1.2%), bite (1.2%), and bed sore (1.2%). Histologic diagnosis were well differentiated SCC(38.6%), SCC, differentiation not reported (24.1%), moderately differentiated SCC (13.2%), BCC (9.6%), poorlydifferentiated SCC (6.0%), melanoma (2.4%), verrucous carcinoma (2.4%), MFH (1.2%), mucoepidermoidcarcinoma (1.2%), and leiomyosarcoma (1.2%). Most of the cases occurred more than 20 years after the initialskin insult. There were 6 (7.2%) cases that developed within 1 year (acute Marjolin's Ulcer). Forty three patients(69.3%) had palpable regional lymph nodes.
Data in this series were in confirmation with many other reports. Marjoln's ulcer should be consideredas a significant post-skin injury complication.
马乔林溃疡是一种罕见的侵袭性疾病，发生于慢性皮肤病变和疾病。在本文中，我们将报告83例该疾病。
我们回顾性检索了83例由慢性皮肤疾病引发癌症的患者记录。记录了人口统计学数据、原始皮肤损伤类型、原始病变与癌症之间的时间间隔、癌症组织学以及淋巴结受累情况。
平均年龄为55.30岁（范围：21 - 90岁）。男性51例（61.5%），女性32例（38.5%）。足部是原发性皮肤病变最常见的部位（49.4%），其次是头皮（15.6%）。原始皮肤损伤为烧伤（87.9%）、骨髓炎（2.4%）、放疗（2.4%）、电烧伤（1.2%）、手术瘢痕（2.4%）、天疱疮（1.2%）、咬伤（1.2%）和压疮（1.2%）。组织学诊断为高分化鳞状细胞癌（38.6%）、未报告分化程度的鳞状细胞癌（24.1%）、中分化鳞状细胞癌（13.2%）、基底细胞癌（9.6%）、低分化鳞状细胞癌（6.0%）、黑色素瘤（2.4%）、疣状癌（2.4%）、恶性纤维组织细胞瘤（1.2%）、黏液表皮样癌（1.2%）和平滑肌肉瘤（1.2%）。大多数病例在初次皮肤损伤后20多年发生。有6例（7.2%）在1年内发病（急性马乔林溃疡）。43例患者（69.3%）可触及区域淋巴结。
本系列数据与许多其他报告一致。马乔林溃疡应被视为皮肤损伤后的一种重要并发症。
