Strýčková Alena, Benko Jakub, Péč Martin Jozef, Péčová Monika, Žolková Jana, Brunclíková Monika, Bolek Tomáš, Staško Ján, Samoš Matej, Mokáň Marián
National Centre of Hemostasis and Thrombosis, Department of Hematology and Blood Transfusion, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Case Rep Hematol. 2022 Aug 25;2022:7805900. doi: 10.1155/2022/7805900. eCollection 2022.
Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.
2019冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的一种急性复杂系统性疾病。虽然已知SARS-CoV-2会导致严重的肺部疾病，但COVID-19的各种肺外表现也有报道。越来越多的证据表明，COVID-19与凝血病有关，可导致微血管和大血管并发症。虽然在COVID-19患者中，静脉血栓栓塞事件更为常见，但动脉血栓形成的发生率也有所增加。这些情况常导致危及生命的急性缺血，需要紧急诊断和治疗。我们报告了两例近期康复的COVID-19患者，其胸主动脉出现异常血栓形成，导致全身栓塞和脾梗死。门诊口服Xa因子抑制剂治疗使两名患者的主动脉血栓均得到溶解。
