Wilhelm David, Caster Dawn, Coventry Susan, Garg Gunjan
Internal Medicine, University of Louisville, Louisville, USA.
Nephrology, University of Louisville, Louisville, USA.
Cureus. 2022 Jul 29;14(7):e27460. doi: 10.7759/cureus.27460. eCollection 2022 Jul.
The association between membranous nephropathy and cancer has been well documented. Crescentic glomerulonephritis (GN) has also been associated with various types of cancers. To our knowledge, there has only been one previously documented case of seronegative pauci-immune crescentic glomerulonephritis associated with colon cancer. We present a case of a 51-year-old male with newly diagnosed high-grade poorly-differentiated colon carcinoma who was found to have seronegative pauci-immune crescentic GN with 70% involvement of glomeruli on renal biopsy. The patient was treated with pulse steroids and rituximab with resolution of acute kidney injury.
膜性肾病与癌症之间的关联已有充分记录。新月体性肾小球肾炎（GN）也与多种类型的癌症有关。据我们所知，此前仅有一例记录在案的与结肠癌相关的血清阴性少免疫性新月体性肾小球肾炎病例。我们报告一例51岁男性，新诊断为高级别低分化结肠癌，肾活检发现其患有血清阴性少免疫性新月体性GN，肾小球受累率达70%。该患者接受了脉冲类固醇和利妥昔单抗治疗，急性肾损伤得以缓解。
