Duran Erdoğan, Taşkın Abdullah, Pehlivan Basak, Çelik Hakim, Pehlivan Veli Fahri, Taşkın Seyhan
Department of Anesthesia and Reanimation, Faculty of Medicine, University of Harran, Sanliurfa, TUR.
Department of Nutrition and Dietetics, Faculty of Medicine, University of Harran, Sanliurfa, TUR.
Cureus. 2022 Jul 31;14(7):e27542. doi: 10.7759/cureus.27542. eCollection 2022 Jul.
Evaluation of the prognosis in the early period of intensive care patients and arranging the treatment accordingly is of vital importance. In the present study, we investigated whether serum thiol/disulphide concentration can be used in the follow-up of prognosis in the early period in patients with COVID-19 under intensive care.
The study included 25 patients [their ages were between 19 and 92; 10 (40%) were male and 15 (60%) were female] who were diagnosed with COVID-19 and treated in the intensive care unit (ICU). The patients were followed for four weeks. On the first, third, and fifth days of intensive care treatment, venous blood samples were taken from the patients to analyze the thiol/disulphide parameters, and coma scores were calculated. Statistical analyses were conducted to evaluate the relationship between thiol/disulphide levels and the prognosis of COVID-19 patients.
At the end of the four-week follow-up of the patients included in the study, 9 were discharged and 16 died. In patients who died, the relationship between thiol/disulphide homeostasis parameters and coma scores was not statistically significant. Meanwhile, in discharged patients, the relationship between disulphide concentration, total thiol, and coma scores was statistically significant.
The relationship between thiol/disulphide homeostasis and coma scores in COVID-19 patients treated in the intensive care unit may help to evaluate the prognosis of the disease in the early period, thus the effectiveness of medical intervention.
评估重症监护患者早期的预后并据此安排治疗至关重要。在本研究中，我们调查了血清硫醇/二硫化物浓度是否可用于重症监护下COVID-19患者早期预后的随访。
该研究纳入了25例在重症监护病房（ICU）确诊并接受治疗的COVID-19患者[年龄在19至92岁之间；男性10例（40%），女性15例（60%）]。对患者进行了四周的随访。在重症监护治疗的第一天、第三天和第五天，采集患者静脉血样以分析硫醇/二硫化物参数，并计算昏迷评分。进行统计分析以评估硫醇/二硫化物水平与COVID-19患者预后之间的关系。
在对纳入研究的患者进行四周随访结束时，9例出院，16例死亡。在死亡患者中，硫醇/二硫化物稳态参数与昏迷评分之间的关系无统计学意义。同时，在出院患者中，二硫化物浓度、总硫醇与昏迷评分之间的关系具有统计学意义。
在重症监护病房接受治疗的COVID-19患者中，硫醇/二硫化物稳态与昏迷评分之间的关系可能有助于在疾病早期评估预后，从而评估医疗干预的有效性。
