Department of Cardiology, Ahi Evran University Training and Research Hospital, Turkey.
Kardiol Pol. 2018;76(2):426-432. doi: 10.5603/KP.a2017.0208. Epub 2017 Nov 13.
Cardiovascular diseases are still one of the leading causes of death in industrialised countries, and oxidative stress plays an important role in the pathogenesis of acute coronary syndromes (ACS). The dynamic thiol/disulphide homeostasis plays an important role in maintaining the oxidant-antioxidant balance.
We aimed to demonstrate the relationship between dynamic thiol/disulphide homeostasis parameters and non-ST elevation ACS (NSTE-ACS).
Patients with NSTE-ACS (n = 210) and a control group (n = 185) were included in the study. The GRACE risk score and the development of major adverse cardiovascular event (MACE) were used to evaluate the prognosis.
Native thiol, total thiol, disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol levels were found to be lower in the NSTE-ACS group (p < 0.001). There was a statistically significant difference between native and total thiol levels in the GRACE risk score subgroups (p < 0.001). There was a correlation between MACE and native thiol levels (p = 0.04).
Consequently, the dynamic thiol/disulphide homeostasis parameters were significantly different in the NSTE-ACS group and may be used to predict prognosis in this patient group.
心血管疾病仍然是工业化国家的主要死亡原因之一，氧化应激在急性冠状动脉综合征（ACS）的发病机制中起着重要作用。动态巯基/二硫键动态平衡在维持氧化还原平衡中起着重要作用。
我们旨在展示动态巯基/二硫键平衡参数与非 ST 段抬高型 ACS（NSTE-ACS）之间的关系。
本研究纳入了 210 例 NSTE-ACS 患者和 185 例对照组患者。使用 GRACE 风险评分和主要不良心血管事件（MACE）的发生来评估预后。
NSTE-ACS 组的天然巯基、总巯基、二硫键/天然巯基、二硫键/总巯基和天然巯基/总巯基水平较低（p<0.001）。GRACE 风险评分亚组之间天然巯基和总巯基水平存在统计学差异（p<0.001）。MACE 与天然巯基水平之间存在相关性（p=0.04）。
因此，NSTE-ACS 组的动态巯基/二硫键平衡参数存在显著差异，可能用于预测该患者群体的预后。
