Kim Hyun Kyung, Kang Eun Young, Go Gwang-Woong
Department of Food and Nutrition, Hanyang University, Seoul, 04763 Korea.
Food Sci Biotechnol. 2022 Aug 20;31(11):1365-1376. doi: 10.1007/s10068-022-01152-6. eCollection 2022 Oct.
The American Heart Association suggests that consuming ω-6 fatty acids (5-10% of total energy) can prevent cardiovascular disease by improving lipoprotein profiles. However, some studies warn of deleterious effects of these due to eicosanoid biosynthesis. We explored the five years for clinical evidence of ω-6 fatty acids on several diseases including inflammation, cancer, cardiovascular disease, and metabolic syndrome. Predefined criteria identified a total of 21 articles in 5 databases. Some studies indicated that dietary arachidonic acid was not related to increase of pro-inflammatory cytokines. In cohort studies, ω-6 fatty acids prevented the onset of digestive and lung cancer. ω-6 Fatty acids improved blood lipoprotein profiles. Moreover, consuming ω-6 fatty acids delayed diabetes mellitus and chronic renal disease and had positive effects on muscle recovery and glaucoma. In conclusion, ω-6 fatty acids have beneficial effects on cancers, blood lipoprotein profiles, diabetes, renal disease, muscle function, and glaucoma without inflammation response.
美国心脏协会建议，摄入ω-6脂肪酸（占总能量的5-10%）可通过改善脂蛋白谱来预防心血管疾病。然而，一些研究警告称，由于类花生酸生物合成，这些脂肪酸会产生有害影响。我们对五年内关于ω-6脂肪酸对包括炎症、癌症、心血管疾病和代谢综合征在内的多种疾病影响的临床证据进行了探究。预定义标准在5个数据库中总共识别出21篇文章。一些研究表明，膳食中的花生四烯酸与促炎细胞因子的增加无关。在队列研究中，ω-6脂肪酸可预防消化道和肺癌的发生。ω-6脂肪酸改善了血液脂蛋白谱。此外，摄入ω-6脂肪酸可延缓糖尿病和慢性肾病，并对肌肉恢复和青光眼有积极影响。总之，ω-6脂肪酸对癌症、血液脂蛋白谱、糖尿病、肾病、肌肉功能和青光眼具有有益作用，且不会引发炎症反应。
