McCormick E M, Echols R M
Antimicrob Agents Chemother. 1987 Apr;31(4):657-9. doi: 10.1128/AAC.31.4.657.
Ciprofloxacin is active in vitro against most bacteria that cause peritonitis associated with peritoneal dialysis. We compared the effects of pH (5.5 and 7.4) and medium (dialysis fluid) on the bactericidal activity of ciprofloxacin, tobramycin, vancomycin plus rifampin, and rifampin against Pseudomonas aeruginosa, Escherichia coli, and three strains of staphylococci. The bactericidal activity of ciprofloxacin was not significantly affected by pH or medium, in contrast to the activity of tobramycin, which was decreased by low pH.
环丙沙星在体外对大多数引起腹膜透析相关腹膜炎的细菌具有活性。我们比较了pH值(5.5和7.4)和培养基(透析液)对环丙沙星、妥布霉素、万古霉素加利福平以及利福平对铜绿假单胞菌、大肠杆菌和三株葡萄球菌的杀菌活性的影响。与妥布霉素的活性不同,环丙沙星的杀菌活性不受pH值或培养基的显著影响,低pH值会降低妥布霉素的活性。