Daigneault Bradford W
Department of Animal Sciences, University of Florida, Gainesville, FL, United States.
Front Genet. 2022 Aug 19;13:909804. doi: 10.3389/fgene.2022.909804. eCollection 2022.
This mini-review focuses on current knowledge regarding maternal regulation of the paternal genome in early embryos of mammalian livestock species. Emphasis has been placed on regulatory events described for maternally imprinted genes and further highlights transcriptional regulation of the post-fertilization paternal genome by maternal factors. Specifically, the included content aims to summarize genomic and epigenomic contributions of paternally expressed genes, their regulation by the maternal embryo environment, and chromatin structure that are indispensable for early embryo development. The accumulation of current knowledge will summarize conserved allelic function among species to include molecular and genomic studies across large domestic animals and humans with reference to founding experimental animal models.
本综述聚焦于目前关于哺乳动物家畜物种早期胚胎中母源对父源基因组调控的知识。重点关注了母源印记基因所描述的调控事件，并进一步强调了母源因子对受精后父源基因组的转录调控。具体而言，所包含的内容旨在总结父源表达基因的基因组和表观基因组贡献、它们受母源胚胎环境的调控以及对早期胚胎发育必不可少的染色质结构。当前知识的积累将总结物种间保守的等位基因功能，包括参考基础实验动物模型对大型家畜和人类进行的分子和基因组研究。
