Department of Animal Sciences, University of Florida, Gainesville, Florida, USA.
Biol Reprod. 2021 Feb 11;104(2):274-281. doi: 10.1093/biolre/ioaa182.
This review focuses on current knowledge of paternal contributions to preimplantation embryonic development with particular emphasis on large animals. Specifically, the included content aims to summarize genomic and epigenomic contributions of paternally expressed genes, their regulation, and chromatin structure that are indispensable for early embryo development. The accumulation of current knowledge will summarize conserved allelic function among species to include functional molecular and genomic studies across large domestic animals in context with reference to founding experimental models.
这篇综述重点介绍了目前关于父本对植入前胚胎发育贡献的知识，特别强调了大动物。具体来说，所包含的内容旨在总结父源表达基因的基因组和表观基因组贡献、它们的调控以及染色质结构，这些对于早期胚胎发育是必不可少的。目前知识的积累将总结物种间保守等位基因功能，包括与参考创始实验模型相关的大型家畜的功能分子和基因组研究。
