Chen Yihong, Shen Junyan, Nilsson Anna Hultgårdh, Goncalves Isabel, Edsfeldt Andreas, Engström Gunnar, Zaigham Suneela, Melander Olle, Orho-Melander Marju, Rauch Uwe, Venuraju Shreenidhi M, Lahiri Avijit, Liang Chun, Nilsson Jan
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
JACC Basic Transl Sci. 2022 Jul 20;7(8):747-762. doi: 10.1016/j.jacbts.2022.03.013. eCollection 2022 Aug.
Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.
肝细胞生长因子（HGF）由应激状态下的人体血管细胞释放，并以自分泌和旁分泌方式促进血管细胞的修复反应。对全身应激反应时HGF表达能力低的受试者心血管风险增加。HGF含量低的人类动脉粥样硬化斑块具有更不稳定的表型。本研究表明，对代谢应激反应时HGF表达能力低的受试者发生心肌梗死和中风的风险增加。
