Su Changming, Chen Jing, Xie Xianrui, Gao Zhongfei, Guan Zhenxin, Mo Xiumei, Wang Chunhua, Hou Guige
School of Pharmacy, Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People's Republic of China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
ACS Omega. 2022 Aug 18;7(34):30137-30148. doi: 10.1021/acsomega.2c03222. eCollection 2022 Aug 30.
Considerable advances have been made in developing materials that promote wound healing and inhibit scar formation in clinical settings. However, some challenges, such as cumbersome treatment processes and determination of optimal treatment time, remain unresolved. Thus, developing a multifunctional wound dressing with both wound healing and scar inhibition properties is crucial. Here, we present an integrated electrospun fibrous composite membrane (MPC12) for wound healing and scar inhibition, consisting of a quaternized chitosan-loaded inner membrane (PCQC5) and quaternized silicone-loaded outer membrane (MQP12). The inner membrane effectively coagulates blood and promotes wound healing, and the outer membrane moisturizes, resists bacteria, and inhibits scar formation. evaluation in a rabbit ear model revealed that MPC12 treatment results in faster wound healing and better alleviation of scar hypertrophy than treatment with commercial products (KELO-COTE and MSSG). Our strategy offers an excellent solution for the potential integration of wound healing and scar inhibition.
在开发促进临床伤口愈合和抑制瘢痕形成的材料方面已经取得了相当大的进展。然而，一些挑战，如繁琐的治疗过程和最佳治疗时间的确定，仍未得到解决。因此，开发一种具有伤口愈合和瘢痕抑制特性的多功能伤口敷料至关重要。在这里，我们展示了一种用于伤口愈合和瘢痕抑制的集成电纺纤维复合膜（MPC12），它由负载季铵化壳聚糖的内膜（PCQC5）和负载季铵化硅氧烷的外膜（MQP12）组成。内膜有效地凝结血液并促进伤口愈合，外膜具有保湿、抗菌和抑制瘢痕形成的作用。在兔耳模型中的评估表明，与商业产品（凯洛格和MSSG）治疗相比，MPC12治疗能使伤口愈合更快，更好地减轻瘢痕增生。我们的策略为伤口愈合和瘢痕抑制的潜在整合提供了一个极佳的解决方案。
