The pharmacophylogenetic relationships of two edible medicinal plants in the genus .

and are edible medicinal plants belonging to the genus in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of and in China and a phylogenetic tree of common medicinal plants in Asteraceae. Then, we verified the chemical composition changes of and via their metabolome. Traditional efficacy and modern pharmacological action were verified by network pharmacology and using RAW264.7 cells. The results showed that and are widely distributed in China, and they shared pharmaphylogeny, which provides theoretical support for the mixed use of and in most regions of China. Furthermore, there were both similarities and differences in volatile oil and flavonoid composition between and . The network pharmacology results showed that and had 23 common active compounds and that both had pharmacological effects on chronic gastritis (CG). Molecular docking analyses showed that quercetin, luteolin, and kaempferol have strong binding affinities with the target proteins JUN, TP53, AKT1, MAPK3, TNF, MAPK, and IL6. The cell experiment results further demonstrated that and treat CG the NOD-like receptor pathway. Based on the theory of pharmaphylogeny, this study explored the pharmaphylogeny between and from various perspectives to provide a basis for the substitution of and .