Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Front Cell Infect Microbiol. 2022 Aug 18;12:934671. doi: 10.3389/fcimb.2022.934671. eCollection 2022.
Pneumonia is one of the leading causes of morbidity and mortality worldwide and Gram-negative bacteria are a major cause of severe pneumonia. Despite advances in diagnosis and treatment, the rise of multidrug-resistant organisms and hypervirulent strains demonstrates that there will continue to be challenges with traditional treatment strategies using antibiotics. Hence, an alternative approach is to focus on the disease tolerance components that mediate immune resistance and enhance tissue resilience. Adaptive immunity plays a pivotal role in modulating these processes, thus affecting the incidence and severity of pneumonia. In this review, we focus on the adaptive T cell responses to pneumonia induced by , , and . We highlight key factors in these responses that have potential for therapeutic targeting, as well as the gaps in current knowledge to be focused on in future work.
肺炎是全球发病率和死亡率的主要原因之一，革兰氏阴性菌是严重肺炎的主要病因。尽管在诊断和治疗方面取得了进展，但多药耐药菌和高毒力菌株的出现表明，使用抗生素的传统治疗策略仍将面临挑战。因此，一种替代方法是专注于介导免疫抵抗和增强组织弹性的疾病耐受成分。适应性免疫在调节这些过程中起着关键作用，从而影响肺炎的发病率和严重程度。在这篇综述中，我们重点介绍了由 、 和 引起的肺炎的适应性 T 细胞反应。我们强调了这些反应中具有潜在治疗靶向的关键因素，以及当前知识中的空白点，这些空白点将是未来工作的重点。
