Department of Cell and Developmental Biology, Penn Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Capstan Therapeutics, Philadelphia, PA, USA.
Nat Metab. 2022 Feb;4(2):163-169. doi: 10.1038/s42255-022-00537-5. Epub 2022 Feb 28.
One of the most exciting new therapies for cancer involves the use of autologous T cells that are engineered to recognize and destroy cancerous cells. Patients with previously untreatable B cell leukaemias and lymphomas have been cured, and efforts are underway to extend this success to other tumours. Here, we discuss recent studies and emerging research aimed to extend this approach beyond oncology in areas such as cardiometabolic disorders, autoimmunity, fibrosis and senescence. We also summarize new technologies that may help to reduce the cost and increase access to related forms of immunotherapy.
一种最令人兴奋的癌症新疗法涉及使用经过基因工程改造以识别和破坏癌细胞的自体 T 细胞。以前无法治疗的 B 细胞白血病和淋巴瘤患者已被治愈，并且正在努力将这一成功扩展到其他肿瘤。在这里，我们讨论了旨在将这种方法从肿瘤学扩展到心脏代谢疾病、自身免疫、纤维化和衰老等领域的最新研究和新兴研究。我们还总结了可能有助于降低成本和增加相关形式免疫疗法的新技术。
