Fatima Urooj, Roy Sonam, Ahmad Shahnawaz, Ali Sabeeha, Elkady Wafaa M, Khan Ilyas, Alsaffar Rana M, Adnan Mohd, Islam Asimul, Hassan Md Imtaiyaz
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
School of Biotechnology, IFTM University, Moradabad, India.
Front Nutr. 2022 Aug 18;9:972379. doi: 10.3389/fnut.2022.972379. eCollection 2022.
has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of extracts (BME), focusing on anti-cancer and neurodegenerative diseases. We examined the clinical studies on phytochemistry and pharmacological application of BME. We further highlighted the mechanism of action of these extracts in varying types of cancer and their therapeutic implications. In addition, we investigated the underlying molecular mechanism in therapeutic interventions, toxicities, safety concerns and synergistic potential in cognition and neuroprotection. Overall, this review provides deeper insights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects.
几个世纪以来，它在阿育吠陀医学中一直被单独使用或与其他草药联合使用，作为一种记忆和学习增强剂、镇静剂和抗癫痫药物。本综述旨在强调婆罗米提取物（BME）的健康益处，重点关注抗癌和神经退行性疾病。我们研究了关于BME植物化学和药理学应用的临床研究。我们进一步强调了这些提取物在不同类型癌症中的作用机制及其治疗意义。此外，我们还研究了治疗干预中的潜在分子机制、毒性、安全问题以及在认知和神经保护方面的协同潜力。总体而言，本综述为婆罗米作为治疗神经系统疾病和发挥认知增强作用的主要配方的治疗意义提供了更深入的见解。
