Coerver Eline M E, Strijbis Eva M M, Petzold Laura F, Van Kempen Zoé L E, Jasperse Bas, Barkhof Frederik, Oudejans Cees B M, Uitdehaag Bernard M J, Teunissen Charlotte E, Killestein Joep
Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Department of Neurology, Maidstone and Tunbridge Wells NHS Trust, Kent, United Kingdom.
Front Neurol. 2022 Aug 17;13:907245. doi: 10.3389/fneur.2022.907245. eCollection 2022.
Myxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.
To investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.
Baseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.
Low MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91-13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.
Baseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.
黏液病毒抗性蛋白A（MxA）是一种受β干扰素上调的蛋白质。稳态MxA mRNA水平可能与多发性硬化症（MS）的炎症疾病活动相关，并可能在MS病理过程中发挥重要作用。
在长期随访期间，研究血液中黏液病毒抗性蛋白A（MxA）mRNA水平与MS疾病活动及进展之间的关联。
测定了116例未经治疗的临床孤立综合征（CIS）或早期复发缓解型MS（RRMS）患者前瞻性队列中的基线血液MxA mRNA水平，并将其与长期复发、放射学疾病活动、临床评分[扩展残疾状态量表（EDSS）、25英尺步行时间（T25FW）、9孔插钉试验（9HPT）]、MS类型和疾病修饰治疗（DMT）的使用情况相关联。
低MxA mRNA水平与MRI成像上≥9个T2病变的出现以及长期随访期间（中位时间11年，四分位间距5.91 - 13.69年）的复发相关。MxA mRNA水平与EDSS、T25FW、9HPT及MS亚型无关。
在我们的队列中，基线MxA mRNA水平与MRI扫描上T2病变的长期发展相关。这证实了内源性β干扰素系统在MS疾病活动发生中的相关性。
