Guo Juan, Hai Hong, Ma Yuewen
Department of Rehabilitation Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Neurol. 2022 Aug 17;13:963849. doi: 10.3389/fneur.2022.963849. eCollection 2022.
Neurological disorders are one of the leading causes of morbidity and mortality worldwide, and their therapeutic options remain limited. Recent animal and clinical studies have shown the potential of extracorporeal shock wave therapy (ESWT) as an innovative, safe, and cost-effective option to treat neurological disorders. Moreover, the cellular and molecular mechanism of ESWT has been proposed to better understand the regeneration and repairment of neurological disorders by ESWT. In this review, we discuss the principles of ESWT, the animal and clinical studies involving the use of ESWT to treat central and peripheral nervous system diseases, and the proposed cellular and molecular mechanism of ESWT. We also discuss the challenges encountered when applying ESWT to the human brain and spinal cord and the new potential applications of ESWT in treating neurological disorders.
神经疾病是全球发病和死亡的主要原因之一，其治疗选择仍然有限。最近的动物和临床研究表明，体外冲击波疗法（ESWT）作为一种创新、安全且具有成本效益的治疗神经疾病的方法具有潜力。此外，ESWT的细胞和分子机制已被提出，以便更好地理解ESWT对神经疾病的再生和修复作用。在这篇综述中，我们讨论了ESWT的原理、涉及使用ESWT治疗中枢和周围神经系统疾病的动物和临床研究，以及ESWT的细胞和分子机制。我们还讨论了将ESWT应用于人类大脑和脊髓时遇到的挑战，以及ESWT在治疗神经疾病方面的新潜在应用。
