Yıldırım Ülkü Miray, Kebudi Rejin
Division of Pediatric Hematology-Oncology, Oncology Institute, Itanbul University, Iİstanbul, Turkey.
Turk Arch Pediatr. 2022 Sep;57(5):566-568. doi: 10.5152/TurkArchPediatr.2022.22004.
Neurofibromatosis 1 is an autosomal dominant inherited tumor susceptibility syndrome. Individuals with neurofibromatosis 1 have a 4-5 times increased risk of malignancy compared to the general population. Central nervous system and soft tissue tumors are common non-hematological malignancies in individuals with neurofibromatosis 1. Although the association of leukemia and non-Hodgkin lymphoma as hematologic malignancies in neurofibromatosis 1 has been reported frequently in the literature in these individuals, association with Hodgkin lymphoma has been reported very rarely.
We presented a patient with neurofibromatosis 1 who further developed Hodgkin lymphoma and reviewed the literature.
Although rare, Hodgkin lymphoma can develop in individuals with neurofibromatosis 1. Hodgkin lymphoma should be kept in mind in cervical/supraclavicular lymphadenomegalies when evaluating patients with neurofibromatosis 1.
神经纤维瘤病1型是一种常染色体显性遗传的肿瘤易感性综合征。与普通人群相比，神经纤维瘤病1型患者发生恶性肿瘤的风险增加4至5倍。中枢神经系统和软组织肿瘤是神经纤维瘤病1型患者常见的非血液系统恶性肿瘤。虽然文献中经常报道神经纤维瘤病1型患者中白血病和非霍奇金淋巴瘤作为血液系统恶性肿瘤的关联，但与霍奇金淋巴瘤的关联报道却非常罕见。
我们报告了1例神经纤维瘤病1型患者继发霍奇金淋巴瘤的病例，并对文献进行了回顾。
虽然罕见，但神经纤维瘤病1型患者可发生霍奇金淋巴瘤。在评估神经纤维瘤病1型患者时，对于颈部/锁骨上淋巴结肿大应考虑到霍奇金淋巴瘤的可能。
