Reveley M A, Reveley A M, Baldy R
Arch Gen Psychiatry. 1987 Jul;44(7):625-32. doi: 10.1001/archpsyc.1987.01800190045008.
Eleven identical (monozygotic) twin pairs discordant for schizophrenia and 18 unselected control monozygotic twin pairs received a computed tomographic scan. Brain absorption density was determined on quadrants at five slice levels using a fully automatic program that eliminated cerebrospinal fluid spaces from analysis. There was no difference in brain density among schizophrenics, co-twins, and controls. There was a significant difference in right vs left hemisphere asymmetry of density across diagnostic groups. Overall, the left hemisphere was less dense than the right in the schizophrenics, while the reverse was found for the co-twins and controls. These results support the hypothesis of left hemisphere dysfunction in schizophrenia and suggest that it is an environmentally acquired, rather than genetic trait.
11对患精神分裂症的同卵双胞胎和18对未经挑选的对照同卵双胞胎接受了计算机断层扫描。使用一个全自动程序在五个切片水平的象限上测定脑吸收密度，该程序在分析中排除了脑脊液间隙。精神分裂症患者、其双胞胎同胞和对照组之间的脑密度没有差异。不同诊断组之间在密度的左右半球不对称性上存在显著差异。总体而言，精神分裂症患者的左半球密度低于右半球，而其双胞胎同胞和对照组则相反。这些结果支持精神分裂症患者左半球功能障碍的假说，并表明这是一种环境获得性特征，而非遗传特征。
