School of Engineering and Agrarian Sciences, Pontifical Catholic University of Argentina (UCA), Institute of Biomedical Research (BIOMED-UCA-CONICET), Buenos Aires, Argentina.
Biochim Biophys Acta Gen Subj. 2022 Dec;1866(12):130239. doi: 10.1016/j.bbagen.2022.130239. Epub 2022 Sep 3.
Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism.
甲状腺激素（THs）在维持心血管稳态中起着至关重要的作用，参与调节心肌收缩力、心率、舒张功能、全身血管阻力和血管舒张。THs 通过激活或抑制靶基因或通过非基因组机制激活细胞内信号来对心血管生理学产生作用。甲状腺功能亢进症改变了某些参与心脏结构和功能保存的细胞内途径，导致相关的心血管疾病。活性氧（ROS）在心血管系统中起着重要作用，但慢性甲状腺功能亢进症引起的 ROS 过度增加以及抗氧化系统的调节与心血管功能障碍的发展有关。在这篇综述中，我们分析了 THs 诱导的氧化应激在导致心脏功能障碍的细胞和分子变化中的作用，以及抗氧化治疗在减轻甲状腺功能亢进症期间发生的心脏异常方面的有效性。
