Gonda T, Akiyoshi H, Ichihara K
Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Japan.
Histol Histopathol. 1995 Jul;10(3):669-72.
The vasoactive intestinal peptide (VIP) immunoreactive nerve fibres in the gallbladder from 14 human patients with cholelithiasis was examined by immunohistochemical method. In the chronic cholecystitis, hyperplastic VIP immunoreactive nerves were observed around the hypertrophied muscle bundles, Rokitansky Aschoff Sinus and in the mucosal layer. However, in the acute cholecystitis and gangrenous cholecystitis, reduction or disappearance of VIP nerve fibres was observed. These reductions or disappearances of VIP immunoreactive nerves may secondly result from severe tissue damage. These results suggest that hyperplastic VIP nerves cause gallbladder relaxation, stasis and mucosal fluid unbalance, which may closely correlate to gallstone formation.
采用免疫组织化学方法检测了14例胆石症患者胆囊中血管活性肠肽（VIP）免疫反应性神经纤维。在慢性胆囊炎中，在肥厚的肌束、罗-阿窦周围及黏膜层观察到VIP免疫反应性神经增生。然而，在急性胆囊炎和坏疽性胆囊炎中，观察到VIP神经纤维减少或消失。这些VIP免疫反应性神经的减少或消失可能继发于严重的组织损伤。这些结果提示，VIP神经增生导致胆囊松弛、胆汁淤积和黏膜液体失衡，这可能与胆结石形成密切相关。
