Adams M R, Kaplan J R, Koritnik D R, Clarkson T B
Arteriosclerosis. 1987 Jul-Aug;7(4):378-84. doi: 10.1161/01.atv.7.4.378.
We investigated the influence of repeated pregnancy on diet-induced atherosclerosis in cynomolgus monkeys and sought to determine if circulating endogenous reproductive steroid levels were associated with the extent of coronary artery atherosclerosis. At necropsy, females which were pregnant one or more times were found to have coronary artery atherosclerosis which was one-fourth as extensive as that of intact females which had not been pregnant. Extent of coronary artery atherosclerosis correlated positively with mean total plasma cholesterol (Rho = 0.52, p less than 0.01) and inversely with high density lipoprotein (HDL) cholesterol (Rho = -0.48, p less than 0.01) concentrations; both decreased during pregnancy. Additionally, the extent of coronary artery atherosclerosis was found to have a strong inverse association (Rho = -0.66, p less than 0.001) with an index (area-under-the-curve) of magnitude and duration of the pregnancy-induced elevation in plasma 17-beta estradiol concentration. This association could not be explained by an interrelationship between estradiol area-under-the-curve and either plasma total or HDL cholesterol concentrations. There was no relationship between atherosclerosis extent and a similar index of plasma progesterone concentrations. These findings provide evidence for an inhibitory effect of endogenous estrogen on the progression of coronary artery atherosclerosis.
我们研究了多次妊娠对食蟹猴饮食诱导的动脉粥样硬化的影响，并试图确定循环内源性生殖类固醇水平是否与冠状动脉粥样硬化的程度相关。尸检时发现，曾怀孕一次或多次的雌性食蟹猴的冠状动脉粥样硬化程度仅为未怀孕的完整雌性食蟹猴的四分之一。冠状动脉粥样硬化程度与血浆总胆固醇均值呈正相关（相关系数Rho = 0.52，p < 0.01），与高密度脂蛋白（HDL）胆固醇浓度呈负相关（相关系数Rho = -0.48，p < 0.01）；二者在孕期均下降。此外，发现冠状动脉粥样硬化程度与孕期血浆17-β雌二醇浓度升高的幅度和持续时间指数（曲线下面积）呈强烈负相关（相关系数Rho = -0.66，p < 0.001）。这种关联无法用雌二醇曲线下面积与血浆总胆固醇或HDL胆固醇浓度之间的相互关系来解释。动脉粥样硬化程度与血浆孕酮浓度的类似指数之间没有关系。这些发现为内源性雌激素对冠状动脉粥样硬化进展的抑制作用提供了证据。
