State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, People's Republic of China.
Inflamm Res. 2022 Nov;71(10-11):1203-1212. doi: 10.1007/s00011-022-01607-w. Epub 2022 Sep 5.
Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A, AA, AB, and A), plays an important role under physiological and pathological conditions. As the receptor with the highest affinity for adenosine, the role of adenosine A receptor (AR)-mediated adenosine signaling pathway in the central nervous system has been well addressed. However, functions of AR on immune cells are less summarized. Considering that some immune cells express multiple types of adenosine receptors with distinct effects and varied density, exogenous adenosine of different concentrations may induce divergent immune cell functions.
The literatures about the expression of AR and its regulation on immune cells and how it regulates the function of immune cells were searched on PubMed and Google Scholar.
In this review, we discussed the effects of AR on immune cells, including monocytes, macrophages, neutrophils, dendritic cells, and microglia, and focused on the role of AR in regulating immune cells in diseases, which may facilitate our understanding of the mechanisms by which adenosine affects immune cells through AR.
腺苷通过介导 G 蛋白偶联的腺苷受体家族（A、AA、AB 和 A）的激活来发挥作用，在生理和病理条件下发挥着重要作用。作为对腺苷具有最高亲和力的受体，腺苷 A 受体（AR）介导的腺苷信号通路在中枢神经系统中的作用已得到很好的阐述。然而，AR 在免疫细胞上的功能却没有得到很好的总结。考虑到一些免疫细胞表达具有不同效应和密度的多种类型的腺苷受体，不同浓度的外源性腺苷可能诱导免疫细胞功能的不同。
在 PubMed 和 Google Scholar 上搜索了关于 AR 的表达及其对免疫细胞的调节，以及它如何调节免疫细胞功能的文献。
在这篇综述中，我们讨论了 AR 对免疫细胞的影响，包括单核细胞、巨噬细胞、中性粒细胞、树突状细胞和小胶质细胞，并重点讨论了 AR 在调节疾病中免疫细胞的作用，这可能有助于我们理解腺苷通过 AR 影响免疫细胞的机制。
