Zhang Xinxin, Xiao Jinfeng, Liu Qi, Ye Yuanyuan, Guo Weihong, Cui Jingqiu, He Qing, Feng Wenli, Liu Ming
Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Int J Endocrinol. 2022 Aug 27;2022:8509204. doi: 10.1155/2022/8509204. eCollection 2022.
There were 1155 patients with T2DM included in the analysis. Serum levels of total testosterone and the precursors of androgens, including androstenedione, DHEA, and DHEAS, were quantified using liquid chromatography-tandem mass spectrometry assays.
The risk of NAFLD decreased as total testosterone concentration increased in men with T2DM. After adjusting for age, current smoking, current drinking, body mass index, duration of T2DM, diastolic blood pressure, total cholesterol, triglycerides, low-density lipoprotein/high-density lipoprotein cholesterol ratio, uric acid, C-reactive protein, and sex hormones in model 4, the adjusted odds ratio (OR) and 95% confidence interval (CI) of NAFLD for tertile3 vs tertile1 was 0.37 (0.17-0.77; = 0.024 for trend). When taken as a continuous variable, this association was still robust in model 4 (OR, 0.58; 95% CI, 0.42-0.80; < 0.05). No significant associations were found between increasing levels of the precursors of androgens and the odds of NAFLD in men with T2DM (all > 0.05). Moreover, women showed no significant associations of total testosterone, androstenedione, DHEA, and DHEAS, with the odds of NAFLD (all > 0.05).
Serum total testosterone was independently associated with the risk of NAFLD among men with T2DM. This study highlights the potential role of testosterone as a risk factor for NAFLD in patients with T2DM.
共有1155例2型糖尿病患者纳入分析。采用液相色谱 - 串联质谱分析法对血清总睾酮及雄激素前体（包括雄烯二酮、脱氢表雄酮和硫酸脱氢表雄酮）水平进行定量分析。
在2型糖尿病男性患者中，随着总睾酮浓度升高，非酒精性脂肪性肝病（NAFLD）风险降低。在模型4中对年龄、当前吸烟状况、当前饮酒状况、体重指数、2型糖尿病病程、舒张压、总胆固醇、甘油三酯、低密度脂蛋白/高密度脂蛋白胆固醇比值、尿酸、C反应蛋白和性激素进行校正后，NAFLD患者三分位数3与三分位数1相比的校正比值比（OR）及95%置信区间（CI）为0.37（0.17 - 0.77；趋势检验P = 0.024）。当将总睾酮作为连续变量时，在模型4中这种关联仍然显著（OR，0.58；95% CI，0.42 - 0.80；P < 0.05）。在2型糖尿病男性患者中，未发现雄激素前体水平升高与NAFLD患病几率之间存在显著关联（所有P > 0.05）。此外，女性患者中总睾酮、雄烯二酮、脱氢表雄酮和硫酸脱氢表雄酮与NAFLD患病几率之间均无显著关联（所有P > 0.05）。
血清总睾酮与2型糖尿病男性患者的NAFLD风险独立相关。本研究强调了睾酮作为2型糖尿病患者NAFLD风险因素的潜在作用。
