Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of post baccalaureate medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Int J Med Sci. 2021 Aug 13;18(15):3470-3477. doi: 10.7150/ijms.63180. eCollection 2021.
The aim of this study was to investigate the associations among obesity-related indices and MetS in diabetic patients, and explore sex differences in these associations. Patients with type 2 DM were included from two hospitals in southern Taiwan. The Adult Treatment Panel III criteria for an Asian population were used to define MetS. In addition, the following obesity-related indices were evaluated: waist-to-height ratio, waist-hip ratio (WHR), conicity index (CI), body mass index (BMI), body roundness index, body adiposity index, lipid accumulation product (LAP), abdominal volume index, visceral adiposity index (VAI), abdominal volume index and triglyceride-glucose index. A total of 1,872 patients with type 2 DM (mean age 64.0 ± 11.3 years, 808 males and 1,064 females) were enrolled. The prevalence rates of MetS were 59.8% and 76.4% in the males and female ( < 0.001), respectively. All of the obesity-related indices were associated with MetS in both sex (all < 0.001). LAP and BMI had the greatest areas under the receiver operating characteristic curves in both sex. In addition, the interactions between BMI and sex ( = 0.036), WHR and sex ( = 0.016), and CI and sex ( = 0.026) on MetS were statistically significant. In conclusion, this study demonstrated significant relationships between obesity-related indices and MetS among patients with type 2 DM. LAP and VAI were powerful predictors in both sex. The associations of BMI, WHR and CI on MetS were more significant in the men than in the women.
本研究旨在探讨肥胖相关指标与糖尿病患者代谢综合征（MetS）之间的关联，并探讨这些关联在性别上的差异。研究对象为来自台湾南部两家医院的 2 型糖尿病患者。采用亚洲人群的成人治疗小组 III 标准来定义 MetS。此外，还评估了以下肥胖相关指标：腰高比、腰围臀围比（WHR）、凸性指数（CI）、体重指数（BMI）、体圆度指数、体脂肪指数、脂质蓄积产物（LAP）、腹部容量指数、内脏脂肪指数（VAI）、腹部容量指数和甘油三酯-葡萄糖指数。共有 1872 名 2 型糖尿病患者（平均年龄 64.0 ± 11.3 岁，男性 808 名，女性 1064 名）入组。男性和女性 MetS 的患病率分别为 59.8%和 76.4%（<0.001）。所有肥胖相关指标在两性中均与 MetS 相关（均<0.001）。LAP 和 BMI 在两性中的受试者工作特征曲线下面积最大。此外，BMI 和性别（=0.036）、WHR 和性别（=0.016）以及 CI 和性别（=0.026）之间的交互作用具有统计学意义。综上所述，本研究表明 2 型糖尿病患者的肥胖相关指标与 MetS 之间存在显著关系。LAP 和 VAI 在两性中均为强有力的预测因子。BMI、WHR 和 CI 与 MetS 的关联在男性中比在女性中更为显著。
