Rahmig Jan, Altarsha Eyad, Siepmann Timo, Barlinn Kristian
Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Neuropsychiatr Dis Treat. 2022 Aug 30;18:1907-1916. doi: 10.2147/NDT.S374549. eCollection 2022.
There have been reports suggesting an increased incidence of acute ischemic stroke among anti-SARS-CoV-2 vaccinees. We aimed to systematically review the literature to summarize the available evidence on the association between SARS-CoV-2 vaccination and acute ischemic stroke.
A systematic literature search on MEDLINE, LitCovid and LIVIVO databases was performed for eligible randomized controlled trials, observational studies, registries and case reports that reported on imaging-confirmed acute ischemic stroke in the context of any SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, Ad26.COV2.S, ChAdOx1 or Gam-COVID-Vac. Literature search was limited to English and German languages and publication date before October 19, 2021.
We identified a total of 395,105,670 individuals who underwent vaccination. We found 21 sources, including 2 cohort studies, 4 registry studies, 3 randomized clinical trials, and 12 case reports. Individuals included in these studies were at least 16 years old. Cari et al observed a higher likelihood of acute ischemic stroke in vaccinees aged 18-64 years, compared to Whiteley et al observing vaccinees older than 70 years when vaccinated. In addition, differences in the likelihood of acute ischemic stroke were found among the vaccines studied, although no overall increased stroke incidence was demonstrated with vaccination.
In this systematic review of the available literature, we found that the risk of acute ischemic stroke does not appear to be increased in vaccinated individuals who have received any of the currently licensed SARS-CoV-2 vaccines compared with the baseline incidence of stroke.
有报告表明，抗SARS-CoV-2疫苗接种者中急性缺血性卒中的发病率有所增加。我们旨在系统回顾文献，总结关于SARS-CoV-2疫苗接种与急性缺血性卒中之间关联的现有证据。
在MEDLINE、LitCovid和LIVIVO数据库中进行系统文献检索，以查找符合条件的随机对照试验、观察性研究、登记处数据和病例报告，这些研究报告了在使用BNT162b2、mRNA-1273、Ad26.COV2.S、ChAdOx1或Gam-COVID-Vac进行任何SARS-CoV-2疫苗接种情况下经影像学确诊的急性缺血性卒中。文献检索限于英语和德语，且发表日期在2021年10月19日之前。
我们共确定了395,105,670名接受疫苗接种的个体。我们找到了21个来源，包括2项队列研究、4项登记处研究、3项随机临床试验和12份病例报告。这些研究纳入的个体年龄至少为16岁。卡里等人观察到18至64岁的疫苗接种者发生急性缺血性卒中的可能性更高，而惠特利等人观察到70岁以上的疫苗接种者接种疫苗时的情况。此外，在所研究的疫苗中发现了急性缺血性卒中发生可能性的差异，尽管疫苗接种并未显示总体卒中发病率增加。
在对现有文献的这项系统评价中，我们发现，与卒中的基线发病率相比，接受任何一种当前已获许可的SARS-CoV-2疫苗接种的个体发生急性缺血性卒中的风险似乎并未增加。
